In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232
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In: Diabetologia, 2015, vol. 58, no. 3, p. 558-565
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In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15
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In: Pflügers Archiv, 2004, vol. 447, no. 5, p. 480-489
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In: Pflügers Archiv, 2004, vol. 448, no. 2, p. 259-260
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In: Human Molecular Genetics, 2015, vol. 24, no. 5, p. 1390-1399
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In: Cell Metabolism, 2014, vol. 19, no. 3, p. 527–538
Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced intracellular...
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In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, no. 42, p. E854-E863
Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that...
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